Isopropyl(4-chlorophenyl)acetyl chloride
3-Methyl-2-(4-chlorophenyl)butyryl chloride
CAS: 51631-50-6
Molecular Formula: C11H12Cl2O
Isopropyl(4-chlorophenyl)acetyl chloride - Names and Identifiers
Isopropyl(4-chlorophenyl)acetyl chloride - Physico-chemical Properties
| Molecular Formula | C11H12Cl2O |
| Molar Mass | 231.12 |
| Density | 1.171g/mLat 25°C(lit.) |
| Boling Point | 124-130°C (3 Torr) |
| Flash Point | >230°F |
| Vapor Presure | 0.00205mmHg at 25°C |
| Refractive Index | n20/D 1.526(lit.) |
| Physical and Chemical Properties | 3-methyl -2-(4-chlorophenyl) butyryl chloride pure as a colorless liquid, B. p.102 ~ 104 ℃/80pa, industrial products are red-brown oily liquid, irritating odor, soluble in organic solvents, easy to absorb moisture decomposition. |
| Use | Pesticide intermediates |
Isopropyl(4-chlorophenyl)acetyl chloride - Risk and Safety
| Hazard Symbols | Xi - Irritant |
| Risk Codes | 36/37/38 - Irritating to eyes, respiratory system and skin. |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36 - Wear suitable protective clothing. |
| WGK Germany | 3 |
Isopropyl(4-chlorophenyl)acetyl chloride - Reference Information
| Uses | 3-methyl -2-(4-chlorophenyl) butyyl chloride is an important intermediate for the preparation of fenvalerate, brommethrin and valerate. Pesticide intermediates. |
| Production method | α-isopropyl p-chlorophenyl acetic acid is obtained by chlorination. α-isopropyl p-chlorophenyl acetic acid and phosphorus pentachloride were mixed in a molar ratio of 1:1.1, stirred and heated to 130 ℃, and reacted at 130-140 ℃ for 1h. After cooling and eliminating the generated hydrogen chloride, the by-product phosphorus oxychloride is evaporated, and the fraction at 100-103 ℃(0.4-0.47kPa) is collected under reduced pressure to obtain α-isopropyl p-chlorophenyl acetyl chloride with a content of more than 95% and a yield of more than 95%. There are several preparation methods. The phosgene method puts 3-methyl -2-(4-chlorophenyl) butyric acid solid into the reaction kettle, a small amount of DMF is used as the catalyst, and after the temperature is raised to the solid melting, a small amount of phosgene is introduced, and the temperature is controlled at 80~90 ℃, and the phosgene is gradually increased. When the phosgene is introduced to a certain amount, the reaction temperature is reduced to 50~60 ℃, and then phosgene is introduced, and the phosgene is introduced to reach the required amount, stop passing the light gas, pass the nitrogen gas at 60~70 ℃ to drive the light gas, and discharge the material after the light gas is exhausted, which is the finished product. Sulfoxide chloride is added into the reaction kettle by sulfoxide chloride method, the temperature is raised to 30-40 ℃, 3-methyl -2-(4-chlorophenyl) butyric acid in molten state is added dropwise, and the temperature is kept at 30-40 ℃ for 0.5h. After the reaction is over, the excess sulfoxide chloride is removed under reduced pressure, and the material is cooled out to obtain the finished product. |
Last Update：2024-04-09 21:21:28
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Product Name: 3-Methyl-2-(4-chlorophenyl)butyryl chloride Request for quotation
CAS: 51631-50-6
Tel: 17505222756
Email: pules.cn@gmail.com
Mobile: +86-17551318830
Wechat: 17505222756
CAS: 51631-50-6
Tel: 17505222756
Email: pules.cn@gmail.com
Mobile: +86-17551318830
Wechat: 17505222756
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